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Abstract #0586

Total Choline Level on MRS Predicts Overall Survival for Endometrial Cancer and Correlates with Tissue Choline Metabolism

Gigin Lin1, Shang-Yueh Tsai2, Yu-Chun Lin1, Chiao-Yun Lin1, Ren-Chin Wu1, and Chyong-Huey Lai1
1Chang Gung Memorial Hospital, Linkou, Taiwan, 2National Chengchi University, Taipei, Taiwan

Endometrial cancer is the most common gynecologic cancer in the developed countries but responses differently to the standard treatment. We aim to investigate and characterize the values of endometrial total choline levels on 1H MR spectroscopy in predicting overall survival, with tissue metabolomics and biochemistry corroboration. We found that increased total choline levels on MRS depicted high-risk cancer group for nodal metastasis, overall survival and disease-free survival for endometrial cancers, supported by increased tissue GPC levels and overexpression of EDI3.

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