Endometrial cancer is the most common gynecologic cancer in the developed countries but responses differently to the standard treatment. We aim to investigate and characterize the values of endometrial total choline levels on 1H MR spectroscopy in predicting overall survival, with tissue metabolomics and biochemistry corroboration. We found that increased total choline levels on MRS depicted high-risk cancer group for nodal metastasis, overall survival and disease-free survival for endometrial cancers, supported by increased tissue GPC levels and overexpression of EDI3.
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