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Abstract #0585

High resolution diffusion and perfusion MRI of normal, preeclamptic and growth-restricted mice models reveal clear fetoplacental differences  

Qingjia Bao1, Eddy Solomon1, Ron Hadas1, Stefan Markovic1, Odelia Chitrit1, Maxime Yon1, Michal Neeman1, and Lucio Frydman1
1Weizmann Institute of Science, Rehovot, Israel

DWI can evaluate pregnancy-related dysfunctions, yet EPI’s sensitivity to motions and air/water/fat heterogeneities complicate these studies in preclinical settings. We have developed DWI methodologies based on SPatiotemporal ENcoding (SPEN) for overcoming these obstacles, delivering single-shot images at ≈100µm in-plane resolutions. These methods were used to monitor fetoplacental differences between naïve and knockout mice strains mimicking preeclampsia and IUGR. High definition ADC/DTI maps could resolve the placental layers (maternal, fetal, trophoblastic), umbilical cords, and various brain compartments in the developing fetuses. Daily monitoring also showed differences in the development of placental and fetal (e.g. brain) structures among normal and disease models.

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