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Abstract #0584

Quantitative Ferumoxytol Dynamic Contrast Enhanced (DCE) MRI Evaluation of the Placenta after Zika Virus Infection in the Rhesus Macaque

Daniel Seiter1, Kai D. Ludwig1, Sydney Nguyen2,3,4, Megan E Murphy2,3,4, Kathleen M Antony2,3,4, Ruiming Chen1, Terry K Morgan5, Ante Zhu6,7, Archana Dhyani8, Sean B Fain1,6,7, Kevin M Johnson1,7, Thaddeus G. Golos2,3,4, and Oliver Wieben1,7
1Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 2Comparative Biosciences, University of Wisconsin-Madison, Madison, WI, United States, 3Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, United States, 4Obstetrics & Gynecology, University of Wisconsin-Madison, Madison, WI, United States, 5Pathology, Oregon Health & Science University, Portland, OR, United States, 6Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, 7Radiology, University of Wisconsin-Madison, Madison, WI, United States, 8Computer Science, University of Wisconsin-Madison, Madison, WI, United States

Proper placental development is crucial to fetal health. Here we report preliminary results characterizing the effects of Zika virus on the placenta of the rhesus macaque using dynamic contrast enhanced (DCE) MRI scans. DCE data were processed to identify individual cotyledons, their volume, and blood flow at three time points during gestation and were compared with pathological findings from term placenta dissection. Analysis shows a statistically significant decrease in cotyledon volume with pathology, measurable as early as 64 days gestation.

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