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Abstract #0589

Diffusion Kurtosis Imaging of Cervical Carcinoma: Correlation between Imaging Parameters and Histological Findings

Qi Zhang1, Xiaoduo Yu1, Jieying Zhang1, Han Ouyang1, Xinming Zhao1, and Lizhi Xie2
1Department of Radiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical, Beijing, China, 2GE healthcare, China, Beijing, China

Cervical cancer is the leading cause of death in gynecological malignancy around the world. The most important prognostic factors include stage at diagnosis, histological subtype, tumor differentiation and et al, which are critical to make the optimal treatment strategies. However, there are still huge challenges in accurate assessment tumor characteristics even by clinical examination and biopsy. DWI has showed promising results in assessment tumor characteristics in cervical cancer. Diffusion kurtosis imaging (DKI), an extension of DWI, is more sensitive to tissue heterogeneity and water exchange. This study demonstrated that DKI-derived parameters are helpful in assessment histological features of cervical cancer.

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