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Abstract #0596

3D-BUDA Enables Rapid Distortion-Free QSM Acquisition

Berkin Bilgic1, Benedikt A Poser2, Christian Langkammer3, Kawin Setsompop1, and Congyu Liao1
1Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2Maastricht University, Maastricht, Netherlands, 3Department of Neurology, Medical University of Graz, Graz, Austria

We introduce 3D blip-up and -down acquisition (3D-BUDA) for 3D echo planar imaging (3D-EPI). We acquire two-shots of 3D-EPI with alternating phase-encoding to estimate B0 information. Incorporating this into the joint reconstruction of the shots eliminates distortion and enables signal averaging, permitting a 22-second, high-SNR acquisition at 1 mm3 resolution. While shifted sampling between the shots provides complementary k-space coverage, using low-rank regularization eliminates shot-to-shot variations. SNR gain of 7T allows for additional partition acceleration, enabling a 9-second whole-brain scan at Rinplane×Rz=5×2. These are combined with a self-supervised dipole inversion algorithm for Quantitative Susceptibility Mapping (QSM) which outperforms state-of-the-art reconstructions.

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