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Abstract #0606

Robust Morphological Myelin Imaging Using a Short TR Adiabatic Inversion Recovery Prepared Ultrashort Echo Time (STAIR-UTE) Sequence

Yajun Ma1, Hyungseok Jang1, Zhao Wei1, Zhenyu Cai1, Yanping Xue1, Eric Y Chang2, Jody Corey-Bloom1, and Jiang Du1
1UC San Diego, San Diego, CA, United States, 2VA health system, San Diego, CA, United States

To image myelin in brain more robustly on clinical scanners, we propose a Short TR Adiabatic Inversion Recovery prepared UTE (STAIR-UTE) sequence for volumetric myelin imaging in vivo. With STAIR technique, long T2 tissues with a broad range of T1s can be sufficiently suppressed. High myelin contrast can be robustly obtained with a TR less than 250 ms. The resultant myelin imaging shows a clear loss of myelin signal in multiple sclerosis (MS) lesions.

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