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Abstract #0607

Direct Saturation Control for Magnetization Transfer Imaging at 7T

David Leitão1, Raphael Tomi-Tricot2, Patrick Liebig3, Rene Gumbrecht3, Dieter Ritter3, Ana Baburamani4, Jan Sedlacik1,4, Joseph V. Hajnal1,4, and Shaihan J. Malik1,4
1Biomedical Engineering Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2MR Research Collaborations, Siemens Healthcare Limited, Frimley, United Kingdom, 3Siemens Healthcare GmbH, Erlangen, Germany, 4Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom

Systems with Magnetization Transfer (MT) are particularly sensitive to $$$B_1^+$$$ inhomogeneity, as the semisolid magnetization saturation is proportional to the square of $$$B_1^+$$$. This can be problematic at 7T imaging, where $$$B_1^+$$$ inhomogeneity is more severe, compromising the MT contrast obtained. This work proposes applying a composite MT prep-pulse with varying RF complex weights for each sub-pulse. These weights are optimized to deliver in the end a homogenous $$$\langle{}B_1^{+2}\rangle$$$, such that the MT contrast obtained is spatially uniform. Simulation and phantom results showed great improvement in the $$$\langle{}B_1^{+2}\rangle$$$ and MT ratio maps.

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