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Abstract #0624

An MRI Method for Labeling and Imaging Decellularized Extracellular Matrix Scaffolds for Tissue Engineering

Daniel Andrzej Szulc1,2, Mohammadali Ahmadipour1,3, Fabio Gava Aoki3,4, Thomas K. Waddell1,3,5, Golnaz of Karoubi5,6,7, and Hai-Ling Margaret Cheng1,2,7,8,9
1Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada, 2Translational Biology & Engineering Program, Ted Rogers Centre for Heart Research, Toronto, ON, Canada, 3Latner Thoracic Surgery Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, 4Biomedical Engineering Laboratory, University of Sao Paulo, Sao Paulo, Brazil, 5Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, Canada, 6Latner Thoracic Surgery Laboratories, University of Toronto, Toronto, ON, Canada, 7Ontario Institute for Regenerative Medicine, Toronto, ON, Canada, 8Heart & Stroke/Richard Lewar Centre of Excellence for Cardiovascular Research, Toronto, ON, Canada, 9Edward S. Rogers Sr. Department of Electrical & Computer Engineering, University of Toronto, Toronto, ON, Canada

Extracellular matrix (ECM) forms the underlying complex structure of bodily tissues, for this reason, ECM has been greatly explored as an ideal scaffold for tissue engineering. To better understand and optimize scaffold-based therapies we require sensitive and non-invasive imaging techniques. In this study, a novel and facile method for labelling and imaging decellularized ECM scaffolds is presented. A series of tissue-specific (bladder, lung, and tracheal smooth muscle and cartilage) dECM scaffolds are labelled with a small molecule manganese porphyrin, MnPNH2. The labelled scaffolds are biocompatible and exhibit significant and sustained signal in vitro and in vivo.

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