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Abstract #0625

Multivalent Gadolinium-decorated Peptides for Versatile Bioconjugation of Molecular MRI Probes

Nikorn Pothayee1, Deepak Sail2, Stephen Dodd1, Rolf Swenson2, and Alan Koretsky1
1Laboratory of Functional and Molecular Imaging, National Institutes of Health, Bethesda, MD, United States, 2Imaging Probe Development Center, National Institutes of Health, Rockville, MD, United States

One of the most important goals of brain imaging is to define the anatomical connections within the brain. In addition to revealing normal circuitry, studies of neural connections and their transports can show rewiring and outgrowth during degeneration following brain injury and diseases. Ultrasensitive agents that can reveal neuroconnectivity and axonal transport dynamics in vivo will be very useful and allow for the interrogation of changes in brain connections and circuitry. In this work, we report two novel MR-visible neural tracers that can be used to visualize neuroconnectivity in vivo.

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