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Abstract #0626

Image-guided tumor resection of head and neck carcinoma (HNSCC) in rabbit models with targeting MRI-Raman nanoprobe

Pengpeng Sun1, Yunfei Zhang2, Kaicheng Li1, Cong Wang3, Feng Zeng3, Jinyu Zhu1, Yongming Dai2, Xiaofeng Tao1, and Yinwei Wu1
1Shanghai Ninth People’s Hospital, Shanghai, China, 2United Imaging Healthcare, Shanghai, China, 3Fudan University, Shanghai, China

Accurately defining infiltrative tumor margin is extremely crucial for complete resection and avoiding mistaken removal of normal tissue. Currently, pre-operative MRI imaging is the most widely-used strategy for defining tumor margin. However, there are plenty of insurmountable disadvantages in terms of accuracy, low resolution, mismatch and so on. This research aims to develop one targeting MRI-Raman nanoprobe able to pre-operatively and intra-operatively evaluate infiltrative margin of head and neck carcinoma (HNSCC) and real-timely guide tumor resection. The results showed that the nanoprobe greatly benefits the complete resection of HNSCC. As a result, the prognosis of tumor-bearing rabbits were considerably improved.

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