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Abstract #0628

mGLUR5 and GABAA Receptor’s Association with fMRI BOLD Signals in the Default Mode Network as Assessed via Simultaneously recorded PET/MR data

Ravichandran Rajkumar1,2,3, Claudia Régio Brambilla1,2,3, Christine Wyss1,4, Shukti Ramkiran1,2, Linda Orth1,2, Joshua Lewis Bierbrier1,5, Elena Rota Kops1, Jürgen Scheins1, Bernd Neumaier6, Johannes Ermert6, Hans Herzog1, Karl Joseph Langen1,3,7, Christoph Lerche1, N. Jon Shah1,3,8,9, and Irene Neuner1,2,3
1Institute of Neuroscience and Medicine 4 (INM-4), Forschungszentrum Jülich, Jülich, Germany, 2Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany, 3JARA – BRAIN – Translational Medicine, Aachen, Germany, 4Department of Psychiatry, Psychotherapy and Psychosomatics, University of Zurich, Zürich, Switzerland, 5Department of Electrical and Computer Engineering, McMaster University, Hamilton, ON, Canada, 6Institute of Neuroscience and Medicine 5 (INM-5), Forschungszentrum Jülich, Jülich, Germany, 7Department of Nuclear Medicine, RWTH Aachen University, Aachen, Germany, 8Institute of Neuroscience and Medicine 11 (INM-11), Forschungszentrum Jülich, Jülich, Germany, 9Department of Neurology, RWTH Aachen University, Aachen, Germany

fMRI-BOLD signals reflect the synaptic activity and glucose energy metabolism in the brain. This study investigated the association between excitatory (mGLUR5), inhibitory (GABAA) neuroreceptors, and glucose metabolism using PET imaging with resting-state fMRI for the first time. The significantly higher mGLUR5 and GABAA neuroreceptor availability and glucose metabolism within the DMN and its correlations show a possible association between increased energy requirements and neuronal activity in the DMN. Further correlations with fMRI measurements show that higher energy demand is utilised for higher functional connectivity, and consecutively higher connectivity within the DMN is more strongly associated with inhibitory receptors.

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