Abstract #0635

Label-free Tracking of Transplanted Mesenchymal Stem Cells Using manCEST MRI

Yue Yuan¹, Congxiao Wang¹, Jia Zhang¹, and Jeff W.M. Bulte¹

¹The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Baltimore, MD, United States

Human mesenchymal stem cells (hMSCs) overexpress high-mannose-type (HM) N-glycans on their membrane surface. Taking advantage of the five exchangeable hydroxyl groups on mannose that provide CEST MRI contrast, we present a label-free method for tracking hMSCs in vivo. The mannose-sensitive CEST (manCEST) signal of hMSCs was clearly distinguishable from the surrounding host tissue and stood out against several other transplanted cell lines tested.

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