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Abstract #0639

Quantitative multiparametric PET-MRI of blood-brain barrier damage after stroke recanalization: nanoparticles versus small contrast agent

Justine Debatisse1,2, Omer Eker3,4, Oceane Wateau5, Tae-Hee Cho1,6, Marlene Wiart1, Nicolas Costes7, Ines Merida7, Christelle Leon1, Jean-Baptiste Langlois7, Thomas Troalen2, Christian Tourvielle7, Thibault Iecker7, Didier Le Bars7, Sophie Lancelot7, Norbert Nighoghossian1,6, Michel Ovize1,8, Hugues Contamin5, Francois Lux9, Olivier Tillement9, and Emmanuelle Canet Soulas1
1CarMeN lab, U1060 INSERM, University of Lyon, Lyon, France, 2Siemens Healthcare SAS, Saint-Denis, France, 3Interventional Neuroradiology, Hospices Civils de Lyon, Lyon, France, 4CREATIS lab, UMR CNRS 5220, INSERM U1206, INSA, University of Lyon, Villeurbanne, France, 5Cynbiose SAS, Marcy l'Etoile, France, 6Neurology, Hospices Civils de Lyon, Lyon, France, 7CERMEP, Lyon, France, 8Cardiology, Hospices Civils de Lyon, Lyon, France, 9ILM, CNRS UMR5306, University of Lyon, Villeurbanne, France

Quantification of blood-brain barrier (BBB) leakage is of main interest in the stroke field to identify patients susceptible to develop hemorrhage and to identify the therapeutic window for neuroprotective drugs administration. We used small (Gd-DOTA) and medium size (nanoparticles AGuIX) contrast agents (CA) to quantify BBB permeability 60-to-90 minutes post-recanalization in a model of stroke using dynamic contrast-enhanced (DCE) MRI. We confirmed 1) Early BBB leakage with both CA and 2) BBB opening to nanoparticles at post-recanalization provides opportunity for selective neuroprotection drug delivery.

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