Meeting Banner
Abstract #0640

Estimation of brown adipose tissue perfusion by DCE-MRI improves measurement of oxidative metabolism by 11C-acetate PET in a rat model

Gabriel Richard1, Christophe Noll1, Mélanie Archambault1, Luc Tremblay1, Serge Phoenix1, Samia Ait-Mohand1, Réjean Lebel1, Brigitte Guérin1, André C. Carpentier1, and Martin Lepage1
1Université de Sherbrooke, Sherbrooke, QC, Canada

Brown adipose tissue (BAT) oxidative metabolism can be measured by 11C-acetate PET with a 3-tissue pharmacokinetic model. However, this model can have trouble distinguishing between increased oxidation and increased blood volume, both of which occur in active BAT. A sequential DCE-MRI and 11C-acetate PET protocol was performed in male Wistar rats with and without BAT activation. DCE-MRI perfusion measures were comparable to those obtained previously with 68Ga-DOTA PET. Incorporating the DCE-MRI blood volume information into the 11C-acetate model revealed higher oxidation in activated BAT than indicated by the unconstrained model.

This abstract and the presentation materials are available to 2020 meeting attendees and eLibrary customers only; a login is required.

Join Here