Abstract #0640

Estimation of brown adipose tissue perfusion by DCE-MRI improves measurement of oxidative metabolism by 11C-acetate PET in a rat model

Gabriel Richard¹, Christophe Noll¹, Mélanie Archambault¹, Luc Tremblay¹, Serge Phoenix¹, Samia Ait-Mohand¹, Réjean Lebel¹, Brigitte Guérin¹, André C. Carpentier¹, and Martin Lepage¹

¹Université de Sherbrooke, Sherbrooke, QC, Canada

Brown adipose tissue (BAT) oxidative metabolism can be measured by ¹¹C-acetate PET with a 3-tissue pharmacokinetic model. However, this model can have trouble distinguishing between increased oxidation and increased blood volume, both of which occur in active BAT. A sequential DCE-MRI and ¹¹C-acetate PET protocol was performed in male Wistar rats with and without BAT activation. DCE-MRI perfusion measures were comparable to those obtained previously with ⁶⁸Ga-DOTA PET. Incorporating the DCE-MRI blood volume information into the ¹¹C-acetate model revealed higher oxidation in activated BAT than indicated by the unconstrained model.

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