Abstract #0642

Whole-body profiling of early cancer metastasis using multimodality reporter gene imaging

Nivin N Nyström^1,2, Timothy J Scholl^2,3, and John Andrew Ronald^1,2,4

¹Medical Biophysics, University of Western Ontario, London, ON, Canada, ²Medical Imaging Laboratories, Robarts Research Institute, London, ON, Canada, ³Medical Biophysics, Robarts Research Institute, London, ON, Canada, ⁴Lawson Health Research Institute, London, ON, Canada

Organic anion-transporting polypeptide 1b3 (Oatp1b3) is a protein derived from the human liver that is capable of taking up Gd-EOB-DTPA, a clinical contrast agent, into cells. We synthetically express the Oatp1b3 gene on breast cancer cells and are able to track them throughout the bodies of preclinical animal models with high sensitivity and resolution as they metastasize. In the future, we hope to develop Oatp1b3 as a tool to track the activation and location of gene and cellular therapies in patients on MRI.

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