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Abstract #0643

The driving force of glymphatics: influence of the cardiac cycle on CSF-mobility in perivascular spaces in humans

Lydiane Hirschler1, Bobby A Runderkamp2, Suzanne L Franklin1,3, Thijs van Harten1, Aart Nederveen2, Matthan WA Caan4, and Matthias JP van Osch1
1Leiden University Medical Center, Leiden, Netherlands, 2Radiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands, 3University Medical Centre Utrecht, Utrecht, Netherlands, 4Department of Biomedical Engineering & Physics, Amsterdam University Medical Center, Amsterdam, Netherlands

Recently, flow of cerebrospinal fluid (CSF) has been shown to play an important role in the waste clearance of the brain, ushering in the concepts of glymphatics and intramural periarterial drainage. Despite the importance of brain waste removal, the exact clearance mechanisms such as its driving force are still poorly understood and remain highly controversial. In this study, we image how the cardiac cycle influences the CSF-mobility in the human brain, in the perivascular spaces of the basal ganglia as well as in large CSF-filled spaces, i.e. ventricles and subarachnoid space around large arteries.

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