Recently, flow of cerebrospinal fluid (CSF) has been shown to play an important role in the waste clearance of the brain, ushering in the concepts of glymphatics and intramural periarterial drainage. Despite the importance of brain waste removal, the exact clearance mechanisms such as its driving force are still poorly understood and remain highly controversial. In this study, we image how the cardiac cycle influences the CSF-mobility in the human brain, in the perivascular spaces of the basal ganglia as well as in large CSF-filled spaces, i.e. ventricles and subarachnoid space around large arteries.
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