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Abstract #0645

Cyclic Intracerebral Coherent Motion on Peripheral-Pulse-Gated Ultra-Low VENC MRI: Noninvasive Depiction of Glymphatic Flow?

Robert Y Shih1,2, J Kevin DeMarco1,2, J Kent Werner1,2, Justin E Costello1,2, Isabelle Heukensfeldt Jansen3, Luca Marinelli3, Thomas K Foo3, and Vincent B Ho1,2
1Uniformed Services University of the Health Sciences, Bethesda, MD, United States, 2Walter Reed National Military Medical Center, Bethesda, MD, United States, 3GE Global Research, Niskayuna, NY, United States

A combination of pressure gradients from arterial pulsatility, respiratory cycles, and resistance changes is thought to drive convective influx of CSF into paraarterial spaces for rapid exchange with ISF, followed by efflux into paravenous spaces toward arachnoid granulations, meningeal lymphatics, or cranial nerves. Visualization of this phenomenon was attempted with peripheral-pulse-gated phase contrast sequences at VENC = 5 mm/s (gradient echo) and 0.24 mm/s (spin echo) in four healthy adults using an ultra-high-performance MAGNUS gradient coil. Very slow intracerebral coherent motion was depicted, cerebropetal during systole, cerebrofugal during diastole, possibly reflecting bulk flow in paravascular spaces of the glymphatic system.

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