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Abstract #0646

Blood flow in the internal carotid arteries is correlated with CSF outflow from the ventricular system

Karin Markenroth Bloch1, Tekla M. Kylkilahti2,3, Olle Haglund1, Linn C. Lingehall2,3, Nils Fregne2,3, Johannes Töger4, and Iben Lundgaard2,3
1National 7T facility, LBIC, Lund University, Lund, Sweden, 2Department of Experimental Medical Science, Lund University, Lund, Sweden, 3Wallenberg Centre for Molecular Medicine, Lund University, Lund, Sweden, 4Department of Clinical Sciences, Lund University, Lund, Sweden

Little is known about which physiological parameters regulate CSF production. In this work, we tested the hypothesis that cerebral blood flow and heart rate play roles in CSF regulation. We used 7T MR to quantify CSF flow in the cerebral aqueduct and blood flow in the carotid arteries of healthy volunteers. We found that CSF outflow from the ventricular system correlated with blood flow in the internal carotid arteries, whereas there was no significant effect of heart rate on CSF outflow. This suggests that cerebral blood flow affects CSF flow and production.

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