Abstract #0648

Impact of cerebrospinal and blood flow pulsatilities on periventricular white matter in patients with hydrocephalus

Fadoua Saadani-Makki^1,2,3, Malek Makki³, Serge Metanbou⁴, Cyrille Capel ⁵, and Olivier Balédent^1,2

¹Department of Image Processing, University Hospital, Amiens, France, ²CHIMERE EA 7516, Research Team for Head & Neck, University of Picardie Jules Verne, Amiens, France, ³GIE Faire Face, CHU Amiens Picardie, Amiens, France, ⁴Department of Radiology, University Hospital, Amiens, France, ⁵Department of Neurosurgery, University Hospital, Amiens, France

The aim of this study was to assess the relationship between neuro-fluids dynamic and microstructure architecture of white matter fibers in hydrocephalus patients. Twenty-eight hydrocephalus patients underwent simultaneously diffusion tensor and phase contrast imaging. A statistical correlation between diffusion and flow parameters has shown a biological causal relationship between abnormal brain neuro-fluids dynamic and white matter alterations in hydrocephalus patients.

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