Using dynamic MRI glymphatic measurement and our advanced mathematic model, the alterations of glymphatic function in the brain with mild TBI were investigated. Our data show that mild TBI leads to both impaired influx and efflux of contrast agent along the glymphatic pathway. The reduced efficiency of glymphatic function affects the multiple regions across the brain, which may decrease the clearance of waste metabolites and facilitate protein aggregation, contributing to subsequent cognitive deficits. The global change in brain clearance function, rather than the appearance of focal lesions, appears to provide a reliable measure indicating the injury of the brain.
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