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Abstract #0650

Cerebrospinal fluid pulse wave velocity measurements using multiband CINE phase-contrast MRI

Kristina Sonnabend1, Gerrit Brinker2, David Maintz1, Alexander Bunck1, and Kilian Weiss1,3
1University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute for Diagnostic and Interventional Radiology, Cologne, Germany, 2University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of General Neurosurgery, Center for Neurosurgery, Cologne, Germany, 3Philips GmbH, Hamburg, Germany

Intraspinal compliance is related to neurological diseases and can be measured by pulse wave velocity (PWV). A multiband CINE phase-contrast MRI sequence was developed to measure the intraspinal PWV between two simultaneously acquired slices along spine. The method was evaluated in-vitro, in healthy-subjects and in a normal pressure hydrocephalus patient. In-vitro results show good reproducibility and dependency on transmural pressure in agreement with theory. A higher PWV compared to healthy subjects is observed in the patient. A decline in PWV after shunt surgery is detected, making it a promising tool for investigation and treatment follow-up of neurological diseases.

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