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Abstract #0689

Metabolism of the hyperpolarized neuroprotective agents [1-13C] lactate and [1-13C] pyruvate in a mouse model of transient ischemic stroke

Thanh Phong Lê1,2, Lara Buscemi3, Elise Vinckenbosch1, Mario Lepore4, Lorenz Hirt3, Jean-Noël Hyacinthe1,5, and Mor Mishkovsky2
1Geneva School of Health Sciences, HES-SO University of Applied Sciences and Arts Western Switzerland, Geneva, Switzerland, 2Laboratory of Functional and Metabolic Imaging, École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland, 3Department of Clinical Neurosciences, Lausanne University Hospital (CHUV), Lausanne, Switzerland, 4Center for Biomedical Imaging - Animal Imaging and Technology (CIBM-AIT), École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland, 5Image Guided Intervention Laboratory, University of Geneva (UNIGE), Geneva, Switzerland

Stroke is a major cause of death and disability. Neuroprotective strategies could ameliorate patient recovery. Pyruvate and lactate were found neuroprotectant in preclinical studies of stroke models. Hyperpolarized 13C MRI provides a new way for real-time molecular imaging. In this work, we hyperpolarize those neuroprotective agents to study changes of their metabolism when administered at their therapeutic dose after ischemic stroke. We found that the metabolism of hyperpolarized lactate is significantly altered after transient cerebral ischemia, whereas moderate changes were depicted with hyperpolarized pyruvate. Those imply that hyperpolarized lactate would potentially be a better theranostic biosensor for stroke.

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