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Abstract #0690

Assessment of Intracranial Metastases in Patients using Hyperpolarized 13C MRI

Casey Y Lee1,2, Hany Soliman3, Benjamin J Geraghty1,2, Nadia D Bragagnolo1,2, Albert P Chen4, William J Perks5, Arjun Sahgal3, Michael W Chan6, Sean Symons7, and Charles H Cunningham1,2
1Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 3Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 4GE Healthcare Technologies, Toronto, ON, Canada, 5Pharmacy, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 6Diagostic Imaging, Trillium Health Partners, Mississauga, ON, Canada, 7Radiology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

Hyperpolarized 13C MRI was used to acquire images of [1-13C]lactate and 13C-bicarbonate from the injected [1-13C]pyruvate in 8 patients with brain metastases. Lesions were manually contoured and the mean tumor 13C-lactate signal was converted to a z-score by extending the approach previously described in Lee et al. (2019). As expected, the z-score ranks of the anatomical regions were less concordant in patients compared to controls. A range of lactate z-scores were observed in metastatic lesions, showing metabolic heterogeneity consistent with the known heterogeneity in metastatic features and clinical status. The lesions with the highest and 5th highest lactate z-scores progressed.

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