Hyperpolarized 13C MRI was used to acquire images of [1-13C]lactate and 13C-bicarbonate from the injected [1-13C]pyruvate in 8 patients with brain metastases. Lesions were manually contoured and the mean tumor 13C-lactate signal was converted to a z-score by extending the approach previously described in Lee et al. (2019). As expected, the z-score ranks of the anatomical regions were less concordant in patients compared to controls. A range of lactate z-scores were observed in metastatic lesions, showing metabolic heterogeneity consistent with the known heterogeneity in metastatic features and clinical status. The lesions with the highest and 5th highest lactate z-scores progressed.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords