Abstract #0691

Hyperpolarized [1-13C] Glycerate as Probe to Assess Glycolytic Activity in a Rat Model of Hepatocellular Carcinoma

Jun Chen¹, Evan LaGue², Junjie Li¹, Edward Hackett¹, Ian Corbin¹, Kelvin Billingsley², and Jae Mo Park^3,4

¹AIRC, UT Southwestern Medical Center at Dallas, Dallas, TX, United States, ²Chemistry and Biochemistry, California State University Fullerton, Fullerton, CA, United States, ³UT Southwestern Medical Center at Dallas, Dallas, TX, United States, ⁴Electrical Engineering, University of Texas at Dallas, Richardson, TX, United States

Hyperpolarized [1-¹³C] glycerate was used to study the in vivo glycolytic activity in a rat model of hepatocellular carcinoma (HCC). Carbon-13 labeled glycolytic intermediate phosphorenolpyruvate (PEP) was detected in the tumor in addition to pyruvate and lactate peaks. The in vivo results were confirmed by high resolution ¹³C NMR spectra of tissue extracts, after steady-state infusion of [2,3-¹³C₂] glycerate. The results illustrate the potential of [1-¹³C] glycerate as a metabolic probe for assessing glycolytic flux.

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