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Abstract #0692

Hyperpolarized 13C Urea laplacian relaxation processing reveals differences between healthy and ischemic renal T2 relaxation.

James Timothy Grist1, Christian Mariager2, and Christoffer Laustsen2
1University of Birmingham, Birmingham, United Kingdom, 2Aarhus University, Aarhus, Denmark

Hyperpoalrized 13C urea T2 relaxometry has been previously used to assess the diabetic and ischemic kidney. In this study we utilise a novel fitting method (Laplacian) to visualise the extent of damage, through a reduction in bi-exponential relaxation behaviour, in a rodent model of renal ischemia.

This opens up a number of potential pre-clinical and clinical uses of hyperpoalrized 13C urea imaging providing a novel, and useful, readout of renal ischemia.

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