Meeting Banner
Abstract #0693

Transportable hyperpolarized glucose samples: towards remote dissolution DNP

Andrea Capozzi1,2, Jan Kilund1, Magnus Karlsson1, Mathilde Hauge Lerche1, and Jan Henrik Ardenkjaer-Larsen1
1Health Technology, Danish Technical University, Kongens Lyngby, Denmark, 2IPHYS, EPFL, Lausanne, Switzerland

Our vision is to enable delivery of hyperpolarized compounds to MR-facilities that currently have no access to hyperpolarization technology. Today this is not the case and represents a main shortcoming of hyperpolarized-MR via dissolution Dynamic Nuclear Polarization (dDNP). The cause is the presence, in the dDNP sample, of organic free radicals necessary to generate the hyperpolarization. We herein present a paradigm shift in the technique built on the employment of photo-induced thermally-labile free radicals. We demonstrate quenching of the paramagnetic species while preserving most of the polarization in the case of hyperpolarized glucose.

This abstract and the presentation materials are available to 2020 meeting attendees and eLibrary customers only; a login is required.

Join Here