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Abstract #0693

Transportable hyperpolarized glucose samples: towards remote dissolution DNP

Andrea Capozzi1,2, Jan Kilund1, Magnus Karlsson1, Mathilde Hauge Lerche1, and Jan Henrik Ardenkjaer-Larsen1
1Health Technology, Danish Technical University, Kongens Lyngby, Denmark, 2IPHYS, EPFL, Lausanne, Switzerland

Our vision is to enable delivery of hyperpolarized compounds to MR-facilities that currently have no access to hyperpolarization technology. Today this is not the case and represents a main shortcoming of hyperpolarized-MR via dissolution Dynamic Nuclear Polarization (dDNP). The cause is the presence, in the dDNP sample, of organic free radicals necessary to generate the hyperpolarization. We herein present a paradigm shift in the technique built on the employment of photo-induced thermally-labile free radicals. We demonstrate quenching of the paramagnetic species while preserving most of the polarization in the case of hyperpolarized glucose.

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