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Abstract #0695

A Metabolite Specific 3D Stack-of-Spiral bSSFP Sequence for Improved Lactate Imaging in Hyperpolarized [1-13C]Pyruvate Studies on a 3T Scanner

Shuyu Tang1, Robert Bok1, Hecong Qin1, Galen Reed2, Mark VanCriekinge1, Romelyn Delos Santos1, William Overall2, Juan Santos2, Jeremy Gordon1, Zhen J. Wang1, Daniel Vigneron1, and Peder E.Z. Larson1
1University of California, San Francisco, San Francisco, CA, United States, 2HeartVista, Los Altos, CA, United States

This work describes a novel 3D bSSFP sequence that integrates a lactate specific excitation pulse and stack-of-spiral readouts for improved lactate dynamic imaging in hyperpolarized [1-13C]pyruvate studies on a clinical 3T scanner. Compared with metabolite specific GRE sequences, the MS-3DSSFP sequence showed an overall 2.5X SNR improvement for lactate imaging in rat kidneys, tumors of TRAMP mice and human kidneys.

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