Abstract #0695

A Metabolite Specific 3D Stack-of-Spiral bSSFP Sequence for Improved Lactate Imaging in Hyperpolarized [1-13C]Pyruvate Studies on a 3T Scanner

Shuyu Tang¹, Robert Bok¹, Hecong Qin¹, Galen Reed², Mark VanCriekinge¹, Romelyn Delos Santos¹, William Overall², Juan Santos², Jeremy Gordon¹, Zhen J. Wang¹, Daniel Vigneron¹, and Peder E.Z. Larson¹

¹University of California, San Francisco, San Francisco, CA, United States, ²HeartVista, Los Altos, CA, United States

This work describes a novel 3D bSSFP sequence that integrates a lactate specific excitation pulse and stack-of-spiral readouts for improved lactate dynamic imaging in hyperpolarized [1-¹³C]pyruvate studies on a clinical 3T scanner. Compared with metabolite specific GRE sequences, the MS-3DSSFP sequence showed an overall 2.5X SNR improvement for lactate imaging in rat kidneys, tumors of TRAMP mice and human kidneys.

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