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Abstract #0696

Providing a clinical pipeline for using the sodium-23 resonance to calibrate for in vivo hyperpolarized carbon-13 experiments.

James Timothy Grist1,2, Esben S Hansen3, Juan D Sanchez4, Mary A McLean5, Frank Riemer6, Rolf F Schulte7, Jan Henrik Ardenkjaer-Larsen4, Christoffer Laustsen3, and Ferdia A Gallagher6
1Unviesity of Cambridge, Cambridge, United Kingdom, 2University of Birmingham, Birmingham, United Kingdom, 3Aarhus University, Aarhus, Denmark, 4Technical University of Denmark, Copenhagen, Denmark, 5Cancer Research UK, Cambridge Institute, University of Cambridge, Cambridge, United Kingdom, 6University of Cambridge, Cambridge, United Kingdom, 7GE Healthcare, Munich, Germany

Hyperpolarized 13C MRI is an emerging clinical technique to probe metabolism. Calibration of transmit gain and centre frequency is challenging, due to the low endogenous 13C signal. Pre-scan is typically performed by adding an external phantom for reference, however this is challenged by the shim volume inside the subject and the RF coil excitation and receptions profiles. We demonstrate the ability to use the sodium-23 resonance to accurately prescan prior to 13C experiments, using single tuned 13C coils in a 3T MRI system. This provides an important workflow improvement for the adoption of hyperpolarized 13C imaging into clinical practise.

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