Abstract #0697

Imaging Acute Metabolic Changes in Mild Traumatic Brain Injury Patients using Hyperpolarized [1-13C]Pyruvate

Edward P Hackett¹, Marco C Pinho², Crystal E Harrison¹, Galen D Reed³, Surendra Barshikar⁴, Christopher J Madden⁵, and Jae Mo Park^1,2,6

¹Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, ²Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, ³GE Healthcare, GE Healthcare, Dallas, TX, United States, ⁴Physical Medicine and Rehabilitation, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁵Neurosurgery, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁶Electrical Engineering, University of Texas Dallas, Richardson, TX, United States

A major challenge of treating traumatic brain injury (TBI) patients is the simultaneously occurring complex secondary injury processes following the primary injury. The secondary events such as cerebral hyperglycolysis and mitochondrial failure develop over minutes to months after the primary injury. This case report details the first time hyperpolarized [1-¹³C]pyruvate imaging in TBI patients to examine regional metabolic changes in the brain post-traumatic injury. We observed an increased conservation of pyruvate to lactate at the injured sites as well as reduced bicarbonate production.

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