Abstract #0713

Modeling cortical architectonic features by analyzing diffusion MRI data in the cortical reference frame

Alexandru V Avram^1,2, Kadharbatcha Saleem^1,2, Frank Q Ye³, Cecil Yen⁴, Michal E Komlosh^1,2, and Peter J Basser¹

¹NICHD, National Institutes of Health, Bethesda, MD, United States, ²The Henry Jackson Foundation, Bethesda, MD, United States, ³NIMH, National Institutes of Health, Bethesda, MD, United States, ⁴NINDS, National Institutes of Health, Bethesda, MD, United States

We quantified the alignment between the DTI reference frame (DRF) and the cortical reference frame (CRF) throughout the entire cerebral cortex in a macaque brain, and found relatively good correspondence, especially in regions with high curvature such as the gyral walls and the cortical sulci. Based on this correspondence, we analyze cortical diffusion signals in the CRF and construct a simple model of cortical diffusion with distinct radial (columnar) and tangential (sheet-like) diffusion processes in cortical layers. The variation of model parameters with cortical depth reflects architectonic features described in a histologically defined digital macaque brain atlas.

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