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Abstract #0714

In vivo observation and interpretation of time-dependent diffusion in human brain gray matter

Hong-Hsi Lee1, Antonios Papaioannou1, Dmitry S Novikov1, and Els Fieremans1
1Center for Biomedical Imaging, Department of Radiology, NYU School of Medicine, New York, NY, United States

The purpose of this work is to identify the relevant microstructural features for the human brain gray matter. For that, we estimate the diffusivity and kurtosis time-dependence in 25 gray matter sub-regions of 10 healthy subjects, and compare the effects of the structural disorder and exchange (Karger model). The estimated power-law dynamical exponent θ≈1/2 is consistent with the structural disorder picture in a 1-dimensional micro-geometry of randomly positioned restrictions along neurites. In contrast, Karger model yields exchange time much shorter than values in previous studies, and below our shortest diffusion time.

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