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Abstract #0715

Water exchange time between gray matter compartments in vivo

Ileana Ozana Jelescu1 and Dmitry S Novikov2
1Center for Biomedical Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 2Dept. of Radiology, New York University School of Medicine, New York, NY, United States

In the absence of a myelin sheath, exchange generally is non-negligible over the typical diffusion times of MRI experiments (10 – 100 ms) and should be accounted for in gray matter modeling. Here we use time-dependent kurtosis and the Kärger model (KM) of two slowly exchanging compartments to evaluate water exchange time between intra-neurite and extra-cellular compartments in rat GM in vivo. We report exchange times on the order of 10 – 30 ms. Future work will focus on exploring a broader range of diffusion times to test the asymptotic decay of kurtosis toward zero.

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