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Abstract #0720

Evidence for Short Range Disorder in the in vivo Human Brain using OGSE Diffusion MRI

Aidin Arbabi1, Jason Kai1, Ali R Khan1, and Corey A Baron1
1Robarts Research Institute, University of Western Ontario, London, ON, Canada

Oscillating gradient spin-echo (OGSE) diffusion MRI enables probing of the frequency content of the apparent diffusion coefficient (ADC). A square root dependence of ADC on frequency has been demonstrated in both healthy and globally ischemic rodent brain tissue, which is consistent with short range structural disorder along neurites. In this work, OGSE data was acquired at multiple frequencies to explore the power law scaling of the ADC in the human brain in vivo, where evidence of a square root dependence of ADC on frequency was obtained for the first time in the in vivo human brain.

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