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Abstract #0719

Oscillating Gradient Diffusion-Encoding In Human Brain Shows Linear Frequency Correlation in High Amplitude and Slew Rate Head Gradient System

Ek T Tan1,2, Robert Y Shih3, Jhimli Mitra1, Yihe Hua1, Tim Sprenger4, Chitresh Bhushan1, Jennifer A McNab5, Matt A Bernstein6, and Thomas KF Foo1
1GE Research, Niskayuna, NY, United States, 2Radiology and Imaging, Hospital for Special Surgery, New York, NY, United States, 3Walter Reed National Military Medical Center, Bethesda, MD, United States, 4GE Healthcare, Stockholm, Sweden, 5Stanford University, Stanford, CA, United States, 6Radiology, Mayo Clinic, Rochester, MN, United States

High gradient amplitude, high gradient slew rate, and high peripheral nerve stimulation thresholds are required for oscillating gradient spin-echo (OGSE) diffusion imaging on human MRI systems. With 200 mT/m amplitude and 500 T/m/s slew rate, the MAGNUS head gradient coil was used to evaluate OGSE imaging in six healthy subjects at frequencies up to 100 Hz and b=450 s/mm2. Comparisons were made against standard pulsed gradient spin-echo (PGSE) diffusion in-vivo, which show up to 27% increased OGSE diffusivity, excellent linear correlation with frequency, and correlation length scales of 0.8┬Ám in white matter. Diffusivity changes were negligible in an isotropic phantom.

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