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Abstract #0718

A unified framework for analysis of time-dependent diffusion: numerical validation of a restriction-exchange correlation experiment

Markus Nilsson1, Carl-Fredrik Westin2, Jan Brabec1, Samo Lasic3, and Filip Szczepankiewicz1
1Clinical Sciences Lund, Lund University, Lund, Sweden, 2Brigham and Women's hospital, Harvard Medical School, Boston, MA, United States, 3Random Walk Imaging AB, Lund, Sweden

Probing time-dependence with diffusion MRI enables mapping of microstructure features such as cell sizes (restrictions) and membrane permeability (exchange). However, restrictions and exchange have opposite effects on the MR signal, and cannot be distinguished by just varying the diffusion time. We propose a unified framework for analysis of time-dependent diffusion that enables the design of efficient restriction-exchange correlation experiments. A signal representation was developed featuring parameters connected to restricted diffusion and exchange. This connection was validated by numerical simulations.

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