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Abstract #0727

Streamline tractography for 3D mapping of axon bundle organization in one MRI voxel using ultra-high resolution synchrotron radiation imaging

Hans Martin Kjer1,2, Mariam Andersson1,2, Yi He2, Marie Louise Elkjaer3, Alexandra Pacureanu4,5, Zsolt Illes3, Bente Pakkenberg6, Anders Bjorholm Dahl1, Vedrana Andersen Dahl1, and Tim B. Dyrby1,2
1DTU Compute, Technical University of Denmark, Kgs. Lyngby, Denmark, 2Danish Research Centre for Magnetic Resonance, Hvidovre, Denmark, 3Department of Neurology, Odense University Hospital, Odense, Denmark, 4X-ray Nanoprobe Group, ID16A, The European Synchrotron, Grenoble, France, 5University College London, London, United Kingdom, 6Research Laboratory for Stereology and Neuroscience, Bispebjerg University Hospital, Copenhagen NV, Denmark

We present an efficient image analysis pipeline that enables us to reveal white matter organization in high-resolution 3D non-MRI structural datasets, in cases where a strict image segmentation is not required nor possible. We apply the method to a synchrotron X-ray holographic tomography scan from a healthy mouse sample, and show the organization of axon bundles in a region covering parts of the corpus callosum and the cingulum. The method has a potential to improve our general understanding of white matter organization and our ability to generate realistic phantoms for validation of microstructure modelling from low-resolution diffusion MRI scans.

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