At the typical spatial resolution of MRI, approximately 60-90% of voxels in the human brain contain multiple fibre populations. Quantifying microstructural properties of distinct fibre bundles within a voxel is challenging. While progress has been made for diffusion and T1-relaxation properties, resolving intra-voxel T2 heterogeneity remains an open question. Here we proposed a novel framework, COMMIT-T2, that uses tractography-based spatial regularization. Unlike previously-proposed voxel-based methods, COMMIT-T2 can recover bundle-specific T2 values within a voxel. Adding this new dimension to the microstructural characterisation of white matter pathways improves the power of tractometry to detect subtle differences in tissue properties.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords