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Abstract #0734

Orientation-dependent biases in powder averaging caused by inhomogeneous distributions of magnetic susceptibility in white matter

Sidsel Winther1,2, Henrik Lundell2, Mariam Andersson1,2, and Tim Dyrby1,2
1DTU Compute, Technical University of Denmark, Kgs. Lyngby, Denmark, 2Danish Research Center for Magnetic Resonance, Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark

Numerical experiments show orientation dependency of the powder averaged diffusion signal (commonly assumed orientation-invariant) when susceptibility-induced inhomogeneity in white matter is taken into account. This implies an axon-orientation-dependent bias of the diffusion signal from white matter regions containing non-uniformly dispersed myelinated axons, which would lead to an over-estimation of the anisotropy. This implies a potential bias between the interpretation of the signal from eg. the internal capsule (oriented inferior-superior) and corpus callosum (oriented left-right).

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