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Abstract #0737

Diffusion ground truth quantification of axon scale phantom: Limits of diffusion MRI on 7T, 3T and Connectome 1.0

Sudhir Pathak1, Walter Schneider1, Anthony Zuccolotto2, Susie Huang3, Qiuyun Fan4, Thomas Witzel5, Lawrence Wald4, Els Fieremans6, Michal E. Komlosh7, Dan Benjamini7, Alexandru V Avram7, and Peter J. Basser7
1University of Pittsburgh, Pittsburgh, PA, United States, 2Psychology Software Tools, Inc, Pittsburgh, PA, United States, 3Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, 4Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, 5Massachusetts General Hospital, Boston, MA, United States, 6Department of Radiology, New York University, New York City, NY, United States, 7National Institutes of Health, Bethesda, DC, United States

We have constructed a novel Taxon (textile water filled tubes) anisotropic diffusion phantom to provide “ground truth” verification of the current limits of diffusion imaging.This phantom is designed to contain 0.8 micron ID tubes with, a packing density of 106 per mm2 , matched to human axon histology, and allows parametric control of diameters, density, and angle dispersion. On a 7T small-bore scanner, we report the ability to distinguish fine Taxon diameter changes between 2-5 micron diameters and approximate 5 micron ID tubes on the 3T Connectome. This is approaching the anatomical scale of axons found in human brain.

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