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Abstract #0738

Comparison of microstructural models of Sodium and Diffusion Basis Spectrum Images

Simona Schiavi1,2, Lazar Fleysher3, Peng Sun4, Nicole Graziano1, Arielle Falcone1, Yongxian Qian5, Fernando E. Boada5, Sheng-Kwei Song4,6,7, and Matilde Inglese1,2,3
1Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2DINOGMI, University of Genoa/IRCCS AOU San Martino-IST, Genoa, Italy, 3Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 4Biomedical MR Laboratory, Department of Radiology, Washington University School of Medicine, St. Louis, MO, United States, 5Department of Radiology, NYU Langone Medical Center, New York, NY, United States, 6Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, United States, 7Biomedical Engineering, Washington University, St. Louis, MO, United States

Both diffusion weighted MRI and Sodium MRI are imaging techniques sensitive to tissue microstructure. The two methods provide complementary information and use tissue models to interpret observed signals to obtain tissue-specific parameters. We investigated the relationship between several tissue-parameters of the two models in the white matter and in the Corpus Callosum. Our results suggests that, the measured cell volume fraction of sodium agrees with diffusion basis spectrum images features. This opens to the possibility of using sodium MRI to investigate pathological tissues and recover complementary information to those we can retrieve with diffusion MRI.

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