Abstract #0738

Comparison of microstructural models of Sodium and Diffusion Basis Spectrum Images

Simona Schiavi^1,2, Lazar Fleysher³, Peng Sun⁴, Nicole Graziano¹, Arielle Falcone¹, Yongxian Qian⁵, Fernando E. Boada⁵, Sheng-Kwei Song^4,6,7, and Matilde Inglese^1,2,3

¹Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²DINOGMI, University of Genoa/IRCCS AOU San Martino-IST, Genoa, Italy, ³Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁴Biomedical MR Laboratory, Department of Radiology, Washington University School of Medicine, St. Louis, MO, United States, ⁵Department of Radiology, NYU Langone Medical Center, New York, NY, United States, ⁶Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, United States, ⁷Biomedical Engineering, Washington University, St. Louis, MO, United States

Both diffusion weighted MRI and Sodium MRI are imaging techniques sensitive to tissue microstructure. The two methods provide complementary information and use tissue models to interpret observed signals to obtain tissue-specific parameters. We investigated the relationship between several tissue-parameters of the two models in the white matter and in the Corpus Callosum. Our results suggests that, the measured cell volume fraction of sodium agrees with diffusion basis spectrum images features. This opens to the possibility of using sodium MRI to investigate pathological tissues and recover complementary information to those we can retrieve with diffusion MRI.

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