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Abstract #0739

Single-shot isotropic diffusion-weighted NMR spectroscopy in the human brain at 7T using tetrahedral encoding

ChloƩ Najac1, Henrik Lundell2, Hermien E. Kan1, Andrew G. Webb1, and Itamar Ronen1
1C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Danish Research Centre for Magnetic Resonance, Copenhagen, Denmark

We propose a single-shot isotropic diffusion-weighted magnetic resonance spectroscopy (DW-MRS) sLASER-based sequence which enables single-shot measurement of metabolite apparent diffusion coefficient (ADC) at relatively short diffusion times and reasonable echo times in the human brain at 7T. Five brain metabolites and water ADC values were measured in two brain regions that differs significantly in white (WM) and grey matter (GM) content. Significantly higher ADCmetabolites and lower ADCwater were observed in WM compared to GM, illustrating microstructural tissue-specific differences.

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