Abstract #0739

Single-shot isotropic diffusion-weighted NMR spectroscopy in the human brain at 7T using tetrahedral encoding

Chloé Najac¹, Henrik Lundell², Hermien E. Kan¹, Andrew G. Webb¹, and Itamar Ronen¹

¹C.J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ²Danish Research Centre for Magnetic Resonance, Copenhagen, Denmark

We propose a single-shot isotropic diffusion-weighted magnetic resonance spectroscopy (DW-MRS) sLASER-based sequence which enables single-shot measurement of metabolite apparent diffusion coefficient (ADC) at relatively short diffusion times and reasonable echo times in the human brain at 7T. Five brain metabolites and water ADC values were measured in two brain regions that differs significantly in white (WM) and grey matter (GM) content. Significantly higher ADC_metabolites and lower ADC_water were observed in WM compared to GM, illustrating microstructural tissue-specific differences.

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