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Abstract #0791

Quantifying the underestimation of myocardial extra cellular volume fraction measurements due to transcytolemmal water exchange

Andrew D Scott1,2, Peter D Gatehouse1,2, and David N Firmin1,2
1CMR Unit, The Royal Brompton Hospital, London, United Kingdom, 2National Heart and Lung Institute, Imperial College London, London, United Kingdom

MR based measures of myocardial extra cellular volume fraction (ECV) obtained from pre and post-contrast T1 mapping are frequently used in research studies. However, typically ECV calculations rely on rapid exchange of water molecules between the intra and extracellular space. We assess the validity of the shutter speed approximation of the full two-compartment model and use this model to assess the effect of limited water exchange rate between the cardiomyocytes and interstitial fluid. For typical conditions used in measuring ECV, we demonstrate an underestimation of ECV on a similar magnitude to the changes attributed to disease in some studies.

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