The unrevealing neuropathology underlying different clinical outcome has blocked effective treatment of schizophrenia. In this study, by prospectively recruited patients at baseline and followed them up for one-year, we have revealed the promising role of disrupted white matter integrity in discriminating good outcome from poor outcome schizophrenia. Further, the baseline white matter integrity in left anterior thalamus radiation is positively correlative with reduction of clinical ratings after one-year in all the patients. These findings indicated the underlying substrates in patients with different clinical outcomes and can serve as the potential imaging characteristic in differentiating these patients before initiating of antipsychotics.
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