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Abstract #0802

Altered resting-state functional activity characterizes white matter function in schizophrenia patients with long-term illness courses

Chengmin Yang1, Wenjing Zhang1, Naici Liu1, Li Yao1, Jiaxin Zeng1, and Su Lui1
1Sichuan University, Chengdu, China

Increasing evidence has suggested white matter (WM) as well raised functional activity in brain and its functional information could be detected by resting-state functional MRI (rs-fMRI). Our study provided new insight into WM functional alterations over the long-term course of schizophrenia with and without the potential effects of antipsychotic medication. Functional changes in the splenium of the corpus callosum (SCC) were found in both treated and untreated patients, which may represent core WM functional changes in schizophrenia.

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