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Abstract #0801

Altered functional synchrony between grey and white matter as a novel indicator of brain system dysconnectvity in schizophrenia

Naici Liu1, Wenjing Zhang1, Chengmin Yang1, Jiaxin Zeng1, Rebekka Lencer2, and Su Lui1
1Sichuan University, Chengdu, China, 2University of Münster, Münster, Germany

Previous studies of white matter (WM) had been limited to structural assessment. In this study, by utilizing resting-state fMRI, the BOLD signals in WM and its functional correlations with BOLD signals in grey matter (GM) were assessed between antipsychotic-naive schizophrenia patients and healthy comparisons. The functional correlation coefficient defined as GM-WM functional synchrony were found widespread altered in patients, especially in WM connecting hemispheres, fronto-temporal, cortico-subcortical regions, and in prefrontal, cingulate, visual, temporal cortex. Additionally, age and illness-duration related alternations in functional synchrony shared the same trend. These findings described schizophrenia as a progressive disorder which was characterized by dysconnectivity.

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