Abstract #0800

A Triple Network Connectivity Study in patients with first episode schizophrenia

Hui Zhang^1,2, Pui Wai Chiu^1,3, Simon S.Y. Lui^4,5, Karen S.Y. Hung⁴, Raymond C.K. Chan^5,6,7, Queenie Chan⁸, P.C. Sham^3,7, Eric F.C. Cheung⁴, and Henry Ka Fung Mak^1,2,3

¹Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, ²Alzheimer's Disease Research Network, Hong Kong, Hong Kong, ³State Key Laboratory of Brain and Cognitive Sciences, Hong Kong, Hong Kong, ⁴Castle Peak Hospital, Hong Kong, Hong Kong, ⁵Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China, ⁶Department of Psychology, University of Chinese Academy of Sciences, Beijing, China, ⁷Department of Psychiatry, The University of Hong Kong, Hong Kong, Hong Kong, ⁸Philips Healthcare, Hong Kong, Hong Kong

To investigate the major psychopathology of first-episode schizophrenia (SCZ), the triple network model consisting of central executive network (CEN), salience network (SN) and default mode network (DMN) was employed. Group-level independent component analysis and group comparison between schizophrenia patients and healthy subjects within networks were applied. In the results, the SCZ group presented significant hyperconnectivity in bilateral insula within SN and hypoconnectivity in occipital lobe and medial prefrontal cortex within DMN. In addition to that, connectivity in bilateral insula within SN showed significant correlation with PANSS scores.

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