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Abstract #0805

Hippocampal Metabolic MR Spectroscopic Imaging Associations with Psychotic and Manic Symptoms in Patients with Schizophrenia

Eyal Lotan1, Dolores Malaspina2, Henry Rusinek1, and Oded Gonen1
1NYU Langone Medical Center, New York, NY, United States, 2Icahn School of Medicine at Mount Sinai, New York, NY, United States

Previous proton MR spectroscopic imaging of the hippocampus distinguished schizophrenia cases from controls by elevated creatine [Cr] and more variable N-acetylaspartate [NAA] and choline [Cho] concentrations. Here we examine these metabolite’s concentrations in 15 cases against their research diagnostic interviews and symptom ratings. Despite modest cohort size we find: (a) elevated [Cho] predicts psychotic; and (b) manic symptoms severity; and (c) lower [NAA] trended with negative symptoms. These findings suggest that microgliosis and demyelination, reflected by reduced [NAA] and elevated [Cho], may be related to active psychotic and manic symptoms, potentially benefiting precision medicine in selection and monitoring schizophrenia treatment.

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