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Abstract #0806

Longitudinal study of quantitative susceptibility mapping in patients with the first episode of psychosis

Marisleydis García1,2,3, Néstor Muñoz1,2,3, Carlos Milovic1,2,3, Luz María Alliende4, Bárbara Iruretagoyena4, Alfonzo Gonzalez5, Julio Acosta Carbonero6, Cristián Montalba2,3, Nicolás Crossley2,4, Sergio Uribe2,3, and Cristián Tejos1,2,3
1Departament Electrical Engineering, Pontificia Universidad Catolica de Chile, Santiago de Chile, Chile, 2Biomedical Imaging Center, Pontificia Universidad Catolica de Chile, Santiago de Chile, Chile, 3Millennium Nucleus for Cardiovascular Magnetic Resonance, Pontificia Universidad Catolica de Chile, Santiago de Chile, Chile, 4Neurology Department, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago de Chile, Chile, 5Instituto Psiquiátrico Horwitz, Santiago de Chile, Chile, 6Tenoke Ltd., Cambridge, United Kingdom

Psychosis has been related with dopamine alterations in deep brain nuclei. Neuromelanin is a by-product of the synthesis of dopamine and it is synthesized via iron-dependent oxidation. Thus, susceptibility might give a window to study the progression of dopamine levels at deep brain nuclei of psychotic patients. We studied a cohort of patients with First Episode of Psychosis (FEP) using QSM at two time points and compared them with healthy controls. We found susceptibility changes in seven subcortical areas at FEP onset. We also found susceptibility changes at the left globus pallidus interna after three months of pharmacological treatment.

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