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Abstract #0825

Clinical Diffusion Time Dependency of Breast Tumors and Associations with Prognostic Factors

Mami Iima1,2, Masako Kataoka1, Maya Honda1, Ayami Ohno Kishimoto1, Rie Ota1, Akane Ohashi1, Yuta Urushibata3, Thorsten Feiweier4, Masakazu Toi5, and Kaori Togashi1
1Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan, 2Clinical Innovative Medicine, Institute for Advancement of Clinical and Translational Science, Kyoto University Hospital, Kyoto, Japan, 3Siemens Healthcare K.K., Tokyo, Japan, 4Siemens Healthcare GMBH, Erlangen, Germany, 5Breast Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan

We investigated the variation of ADC values obtained at diffusion times that are clinically available for differentiation of human breast tumors. The ADC values in both malignant and benign breast tumors decreased with increased diffusion time, and a larger change in ADC values was found in malignant tumors. The significant association found between ADC change and Ki-67 expression might indicate the potential of diffusion time-dependent ADC values as a tool to differentiate these prognostic biomarkers and assess tumor heterogeneity without the need for contrast agents.

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