Abstract #0825

Clinical Diffusion Time Dependency of Breast Tumors and Associations with Prognostic Factors

Mami Iima^1,2, Masako Kataoka¹, Maya Honda¹, Ayami Ohno Kishimoto¹, Rie Ota¹, Akane Ohashi¹, Yuta Urushibata³, Thorsten Feiweier⁴, Masakazu Toi⁵, and Kaori Togashi¹

¹Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan, ²Clinical Innovative Medicine, Institute for Advancement of Clinical and Translational Science, Kyoto University Hospital, Kyoto, Japan, ³Siemens Healthcare K.K., Tokyo, Japan, ⁴Siemens Healthcare GMBH, Erlangen, Germany, ⁵Breast Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan

We investigated the variation of ADC values obtained at diffusion times that are clinically available for differentiation of human breast tumors. The ADC values in both malignant and benign breast tumors decreased with increased diffusion time, and a larger change in ADC values was found in malignant tumors. The significant association found between ADC change and Ki-67 expression might indicate the potential of diffusion time-dependent ADC values as a tool to differentiate these prognostic biomarkers and assess tumor heterogeneity without the need for contrast agents.

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