Abstract #0826

Cortical Surface Spectral Matching of the Fetal Brain Pre and Post Fetal Surgery for Open Spina Bifida

Nada Mufti^1,2,3, Michael Aertsen⁴, Michael Ebner^2,3, Lucas Fidon², Tom Vercauteren^2,5, Luc De Catte⁵, Philippe Demaerel⁴, Jan Deprest^1,5, Sebastien Ourselin², Anna L David^1,6, and Andrew Melbourne^2,3

¹Institute for Women's Health and Department of Medical Physics and Biomedical Engineering, University College London (UCL), London, United Kingdom, ²School of Biomedical Engineering and Imaging Sciences (BMEIS), King's College London, London, United Kingdom, ³Department of Medical Physics and Biomedical Engineering, University College London (UCL), London, United Kingdom, ⁴Department of Radiology, University Hospitals Katholieke Universiteit (KU) Leuven, Leuven, Belgium, ⁵Department of Obstetrics and Gynaecology, University Hospitals Katholieke Universiteit (KU) Leuven, Leuven, Belgium, ⁶University Hospitals KU Leuven, Leuven, Belgium

Comprehensive evaluation of the fetal central nervous system (CNS) is required to select the most suitable candidates, to counsel parents about fetal spina bifida surgery, and to monitor post-op response. In children and adolescents with spina bifida, MRI assessment of gyrification correlates with motor and cognitive function. Our aim is to determine if MRI can quantify fetal brain gyrification and folding before and after fetal spina bifida surgery. If successful, mapping the gyrification changes to different lobes in the brain may prove useful in the prediction of motor and cognitive function after fetal surgery.

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