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Abstract #0826

Cortical Surface Spectral Matching of the Fetal Brain Pre and Post Fetal Surgery for Open Spina Bifida

Nada Mufti1,2,3, Michael Aertsen4, Michael Ebner2,3, Lucas Fidon2, Tom Vercauteren2,5, Luc De Catte5, Philippe Demaerel4, Jan Deprest1,5, Sebastien Ourselin2, Anna L David1,6, and Andrew Melbourne2,3
1Institute for Women's Health and Department of Medical Physics and Biomedical Engineering, University College London (UCL), London, United Kingdom, 2School of Biomedical Engineering and Imaging Sciences (BMEIS), King's College London, London, United Kingdom, 3Department of Medical Physics and Biomedical Engineering, University College London (UCL), London, United Kingdom, 4Department of Radiology, University Hospitals Katholieke Universiteit (KU) Leuven, Leuven, Belgium, 5Department of Obstetrics and Gynaecology, University Hospitals Katholieke Universiteit (KU) Leuven, Leuven, Belgium, 6University Hospitals KU Leuven, Leuven, Belgium

Comprehensive evaluation of the fetal central nervous system (CNS) is required to select the most suitable candidates, to counsel parents about fetal spina bifida surgery, and to monitor post-op response. In children and adolescents with spina bifida, MRI assessment of gyrification correlates with motor and cognitive function. Our aim is to determine if MRI can quantify fetal brain gyrification and folding before and after fetal spina bifida surgery. If successful, mapping the gyrification changes to different lobes in the brain may prove useful in the prediction of motor and cognitive function after fetal surgery.

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